Pharmacologic Substance
azacitidine Audio
[ ay-zuh-sy-tih-deen ]
Brand Names:
Onureg; Vidaza
Effect:
DNA Methylation Decrease
May Treat:
Anemia, Refractory; Anemia, Sideroblastic; Leukemia, Myelomonocytic, Chronic
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to azacitidine:
  • A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called antimetabolites.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A pyrimidine analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Pyrimidine analog that inhibits DNA methyltransferase, impairing DNA methylation, also an antimetabolite of cytidine, incorporated primarily into RNA; has been used as an antineoplastic agent.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.