Pharmacologic Substance
betaxolol
Brand Names:
Betoptic S; Kerlone
Effect:
Decreased Blood Pressure; Decreased Intraocular Aqueous Secretion; Negative Chronotropy; Negative Inotropy
May Treat:
Glaucoma, Open-Angle; Hypertension
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to betaxolol:
  • A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A racemic mixture and selective beta-1 adrenergic receptor antagonist with antihypertensive and anti-glaucoma activities and devoid of intrinsic sympathomimetic activity. Betaxolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. When applied topically in the eye, this agent reduces aqueous humor secretion and lowers the intraocular pressure (IOP). In addition, betaxolol prevents the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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