Pharmacologic Substance
penbutolol
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Negative Chronotropy; Negative Inotropy
May Treat:
Angina Pectoris; Hypertension; Myocardial Infarction
Definitions related to penbutolol:
  • A lipophilic, nonselective beta-adrenergic receptor antagonist with anti-anginal and antihypertensive activities. Penbutolol competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, penbutolol prevents the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A nonselective beta-blocker used as an antihypertensive and an antianginal agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.