Pharmacologic Substance
budesonide Audio
[ byoo-deh-suh-nide ]
Brand Names:
Breztri; Entocort; Ortikos; Pulmicort; Rhinocort; Symbicort; Uceris
Effect:
Decreased Cellular Migration; Decreased Glucocorticoid Secretion; Decreased Lysosomal Function; Decreased Protein Synthesis
May Prevent:
Asthma; Nasal Polyps
May Treat:
Inflammatory Bowel Diseases; Rhinitis, Allergic, Perennial
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to budesonide:
  • A drug used in the treatment of asthma and rhinitis. It is also being studied in the treatment of cancer. Budesonide belongs to the family of drugs called steroids.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon administration, budesonide binds to intracellular glucocorticoid receptors (GRs) and induces the expression of glucocorticoid-responsive genes that encode for anti-inflammatory mediators, such as certain anti-inflammatory cytokines, including interleukin 10 (IL-10), and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, budesonide prevents the release of pro-inflammatory cytokines from epithelial cells and macrophages, including interleukin 6 (IL-6), IL-8, interferon-beta (IFNb), and inhibits nuclear factor kappa-B (NF-kB) activation thereby decreasing NF-kB-mediated inflammation.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.