Antibiotic
cefuroxime
Brand Names:
Ceftin
Effect:
Decreased Cell Wall Synthesis & Repair
May Prevent:
Surgical Wound Infection
May Treat:
Bone Diseases, Infectious; Escherichia coli Infections; Gonorrhea; Haemophilus Infections; Impetigo; Klebsiella Infections; Lyme Disease; Meningitis, Bacterial; Pharyngitis; Pneumonia, Bacterial; Proteus Infections; Sepsis; Sinusitis; Soft Tissue Infections; Surgical Wound Infection; Urinary Tract Infections
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to cefuroxime:
  • A semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.