Antibiotic
ceftriaxone
[ sef-try-ak-sone ]
Effect:
Decreased Cell Wall Synthesis & Repair
May Prevent:
Surgical Wound Infection
May Treat:
Acinetobacter Infections;
Bacteroidaceae Infections;
Bone Diseases, Infectious;
Chancroid;
Clostridium Infections;
Enteritis;
Epididymitis;
Escherichia coli Infections;
Gonorrhea;
Klebsiella Infections;
Lyme Disease;
Meningitis, Bacterial;
Otitis Media;
Pelvic Infection;
Peritonitis;
Pneumonia, Bacterial;
Proctocolitis;
Proteus Infections;
Pseudomonas Infections;
Salmonella Infections;
Sepsis;
Serratia Infections;
Skin Diseases, Bacterial;
Soft Tissue Infections;
Staphylococcal Infections;
Streptococcal Infections;
Urinary Tract Infections
More Information:
Definitions related to ceftriaxone:
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A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).NCI ThesaurusU.S. National Cancer Institute, 2021
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A broad-spectrum cephalosporin antibiotic and cefotaxime derivative with a very long half-life and high penetrability to meninges, eyes and inner ears.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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