Research Activity
cross-over study
Subclass of:
Epidemiologic Research Design
Definitions related to cross-over studies:
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(crossover) Participants receive one of two or more alternative intervention(s) during the initial epoch of the study and receive other intervention(s) during the subsequent epoch(s) of the study.CDISC TerminologyClinical Data Interchange Standards Consortium (CDISC), 2021
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(crossover trial) A trial design for which subjects function as their own control and are assigned to receive investigational product and controls in an order determined by randomizations, typically with a washout period between the two products.CDISC TerminologyClinical Data Interchange Standards Consortium (CDISC), 2021
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(crossover study) A type of clinical study in which each study subject receives the same series of treatments but in a random order that differs across arms of the study. Each subject serves as their own control in this type of study.NCI ThesaurusU.S. National Cancer Institute, 2021
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Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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