Hormone
dihydrotestosterone
di·hy·dro·tes·tos·ter·one [ dy-hy-droh-tes-tos-teh-rone ]
Subclass of:
Testosterone Congeners;
Androstanols
Definitions related to dihydrotestosterone:
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A form of the hormone testosterone that spurs the prostate gland to enlarge (benign prostatic hyperplasia).Harvard Dictionary of Health TermsHarvard Medical Publishing, 2011
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A hormone made from testosterone in the prostate, testes, and certain other tissues. It is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. High amounts of androstanolone may increase the growth of prostate cancer and make it harder to treat.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Potent androgenic metabolite of testosterone; dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone; unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid.CRISP ThesaurusNational Institutes of Health, 2006
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The most potent androgen, required for sex development. Dihydrotestosterone is synthesized from testosterone in the prostate gland, testes, hair follicles and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates specific nuclear androgen receptors. After translocation into the nucleus, the activated hormone-receptor complex binds to the androgen response elements on the DNA and activates gene expressions that are required for sex development. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice.NCI ThesaurusU.S. National Cancer Institute, 2021
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(therapeutic androstanolone) A therapeutic anabolic steroid hormone identical to endogenous dihydrotestosterone. Androstanolone binds to and activates specific nuclear receptors. This agent may be used for testosterone replacement therapy in hypogonadal men, in HIV-wasting syndrome, and in other conditions in order to increase nitrogen retention and fat-free muscle mass. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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