Pharmacologic Substance
erlotinib hydrochloride Audio
[ er-loh-tih-nib hy-droh-klor-ide ]
Effect:
Cellular Division Phase Alteration; Cellular Growth Phase Reduction; Increased Cellular Death; Vascular Growth Decrease
May Treat:
Carcinoma, Non-Small-Cell Lung
More Information:
ChemID; DailyMed; PDR
Definitions related to erlotinib hydrochloride:
  • A drug used to treat certain types of non-small cell lung cancer. It is also used together with gemcitabine to treat pancreatic cancer and is being studied in the treatment of other types of cancer. Erlotinib hydrochloride is a type of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine kinase. It is used in the treatment of NON-SMALL CELL LUNG CANCER.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The hydrochloride salt of a quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.