Pharmacologic Substance
trimetrexate
Effect:
Decreased DNA Replication; Decreased Protein Synthesis; Decreased RNA Replication
May Treat:
Pneumonia, Pneumocystis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to trimetrexate:
  • 2,4-diamino-5-methyl-6-(3,4,5-trimethoxy anilinomethyl)quinazoline; one of the most widely used cancer chemotherapeutic agents.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.