Pharmacologic Substance
etretinate
Effect:
Decreased Skin Keratinization
May Treat:
Psoriasis
Definitions related to etretinate:
  • A synthetic oral retinoid that is a prodrug of acitretin. Etretinate activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. Etretinate is no longer commercially available in the U.S. due to the extended potential for teratogenic effects related to its long half-life. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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