Pharmacologic Substance
isotretinoin Audio
[ i-soh-treh-tih-noyn ]
Brand Names:
Absorica; Accutane; Amnesteem; Claravis; Myorisan; Sotret; Zenatane
Effect:
Decreased Sebaceous Gland Activity
May Treat:
Acne Vulgaris; Leukemia; Neuroblastoma
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to isotretinoin:
  • A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (13-cis retinoic acid) A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.