Pharmacologic Substance
fluticasone
Brand Names:
Advair; AirDuo; Aller-Flo; Armonair; Arnuity; Beser; Breo; Clarispray; Cutivate; Dymista; Flonase; Flonase Sensimist; Flovent; Fluticare; Nasoflow; Nasopro 24; Trelegy; Veramyst; Wixela; Xhance
Effect:
Decreased Capillary Permeability; Decreased Fibroblast Migration; Decreased Glucocorticoid Secretion; Decreased Lysosomal Function; Decreased Polymorphonuclear Leukocyte Migration; Decreased Protein Synthesis
May Prevent:
Asthma; Nasal Polyps
May Treat:
Rhinitis, Allergic, Perennial
More Information:
Definitions related to fluticasone:
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A STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Fluticasone binds and activates glucocorticoid receptor, resulting in the activation of lipocortin. Lipocortin, in turn, inhibits cytosolic phospholipase A2, which triggers a cascade of reactions involved in the synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.NCI ThesaurusU.S. National Cancer Institute, 2021
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