Pharmacologic Substance
loteprednol etabonate
Brand Names:
Alrex; Eysuvis; Inveltys; Lotemax; Zylet
Effect:
Decreased Leukotriene Activity; Decreased Prostaglandin Activity; Decreased Thromboxane Activity
May Treat:
Conjunctivitis, Allergic;
Conjunctivitis, Bacterial;
Conjunctivitis, Viral;
Edema;
Inflammation;
Iritis;
Keratitis;
Rosacea
More Information:
Definitions related to loteprednol etabonate:
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An androstadiene derivative corticosteroid that is used as an ANTI-ALLERGIC AGENT for the treatment of inflammatory and allergic eye conditions.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The etabonate salt form of loteprednol, an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. Loteprednol etabonate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Loteprednol etabonate specifically induces phospholipase A2 inhibitory proteins (collectively called lipocortins), which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes.NCI ThesaurusU.S. National Cancer Institute, 2021
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