Disease or Syndrome
Huntington's disease
Subclass of:
Heredodegenerative Disorders, Nervous System;
Basal Ganglia Diseases;
Cognition Disorders;
Dementia;
Chorea
Also called:
Chronic Progressive Chorea; Hereditary Chorea; Huntington Chorea; Huntington's Disease; HD; Huntington's chorea
Definitions related to huntington disease:
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A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Huntington disease (HD) is a progressive disorder of motor, cognitive, and psychiatric disturbances. The mean age of onset is 35 to 44 years, and the median survival time is 15 to 18 years after onset.GeneReviewsUniversity of Washington, 2021
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(huntington's disease) A progressive hereditary neurodegenerative disorder inherited in an autosomal dominant fashion. Symptoms may appear at any age and include uncontrolled movements, clumsiness, balance problems, difficulty walking, talking, or swallowing. The disease has a progressive course with a decline in mental abilities, and the development of psychiatric problems.NCI ThesaurusU.S. National Cancer Institute, 2021
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(huntington's disease) An inherited disorder characterized by involuntary jerky movements and dementia.Harvard Dictionary of Health TermsHarvard Medical Publishing, 2011
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(huntington's disease) Chronic progressive chorea and mental deterioration terminating in dementia; the age of onset usually is in the fourth decade of life.CRISP ThesaurusNational Institutes of Health, 2006
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(huntington's disease) Huntington's disease (HD) is an inherited disease that causes certain nerve cells in the brain to waste away. People are born with the defective gene, but symptoms usually don't appear until middle age. Early symptoms of HD may include uncontrolled movements, clumsiness, and balance problems. Later, HD can take away the ability to walk, talk, and swallow. Some people stop recognizing family members. Others are aware of their environment and are able to express emotions. If one of your parents has Huntington's disease, you have a 50 percent chance of getting it. A blood test can tell you if have the HD gene and will develop the disease. Genetic counseling can help you weigh the risks and benefits of taking the test. There is no cure. Medicines can help manage some of the symptoms, but cannot slow down or stop the disease. NIH: National Institute of Neurological Disorders and StrokeMedlinePlusU.S. National Library of Medicine, 2021
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Huntington disease is an autosomal dominant disorder characterized by chorea, neuropsychiatric symptoms, and progressive cognitive deterioration, usually beginning during middle age. Diagnosis is by genetic testing. First-degree relatives should be offered genetic counseling before genetic tests are done. Treatment is supportive.Merck & Co., Inc., 2020
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Huntington disease (HD) is an incurable, adult-onset, autosomal dominant inherited disorder associated with cell loss within a specific subset of neurons in the basal ganglia and cortex. HD is named after George Huntington, the physician who described it as hereditary chorea in 1872.WebMD, 2019
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Huntington's disease is a rare, inherited disease that causes the progressive breakdown (degeneration) of nerve cells in the brain. Huntington's disease has a broad impact on a person's functional abilities and usually results in movement, thinking (cognitive) and psychiatric disorders.Mayo Foundation for Medical Education and Research
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Huntington disease (HD) is an inherited condition that causes progressive degeneration of neurons in the brain. Signs and symptoms usually develop between ages 35 to 44 years and may include uncontrolled movements, loss of intellectual abilities, and various emotional and psychiatric problems. People with HD usually live for about 15 to...National Center for Advancing Translational Sciences
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Huntington disease is a slowly progressive, neurodegenerative disorder characterized by chorea, incoordination, cognitive decline, personality changes, and psychiatric symptoms, culminating in immobility, mutism, and inanition. It is an autosomal dominant, trinucleotide repeat disorder that affects men and women equally. It...Athenahealth, Inc., 2019
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Huntington disease , a relatively rare, and invariably fatal, hereditary neurological disease that is characterized by irregular and involuntary movements of the muscles and progressive loss of cognitive ability. The disease was first described by American physician George Huntington in 1872....Encyclopedia Britannica, Inc., 2020
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