Pharmacologic Substance
idoxuridine Audio
[ ahy-doks-yoo r-i-deen ]
Effect:
Nucleic Acid Replication Alteration
May Treat:
Keratitis, Dendritic
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to idoxuridine:
  • A drug that reduces the risk of cancer cell growth by interfering with the cells' DNA.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Pyrimidine analog which inhibits viral DNA synthesis.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.