Pharmacologic Substance
indomethacin Audio
in·do·meth·a·cin [ in-doh-meth-uh-sin ]
Brand Names:
Indocin; Tivorbex
Effect:
Decreased Prostaglandin Production
May Treat:
Arthritis, Gouty; Arthritis, Rheumatoid; Bursitis; Ductus Arteriosus, Patent; Inflammation; Osteoarthritis; Pain; Spondylitis, Ankylosing; Tendinopathy
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to indomethacin:
  • A drug that reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs. It is a type of nonsteroidal anti-inflammatory drug (NSAID).
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Non-steroidal anti-inflammatory agent that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids; also inhibits the motility of polymorphonuclear leukocytes.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.