Pharmacologic Substance
ketorolac
[ kee-tor-oh-lak ]
Brand Names:
Acular; Acuvail; Omidria; Sprix
Effect:
Decreased Prostaglandin Production
May Prevent:
Pain
May Treat:
Pain
More Information:
Definitions related to ketorolac:
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A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation.NCI ThesaurusU.S. National Cancer Institute, 2021
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