Pharmacologic Substance
lomustine Audio
[ loh-mus-teen ]
Brand Names:
Gleostine
Effect:
Decreased DNA Integrity; Decreased DNA Replication; Decreased Transcription to RNA
May Treat:
Brain Neoplasms; Colonic Neoplasms; Hodgkin Disease; Kidney Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Melanoma
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to lomustine:
  • A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An alkylating agent of value against both hematologic malignancies and solid tumors.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An anticancer drug that belongs to the family of drugs called alkylating agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Cytotoxic alkylating agent of the nitrosourea group used as an antineoplastic.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.