Pharmacologic Substance
lomustine
[ loh-mus-teen ]
Brand Names:
Gleostine
Effect:
Decreased DNA Integrity; Decreased DNA Replication; Decreased Transcription to RNA
May Treat:
Brain Neoplasms;
Colonic Neoplasms;
Hodgkin Disease;
Kidney Neoplasms;
Lung Neoplasms;
Lymphoma, Non-Hodgkin;
Melanoma
More Information:
Definitions related to lomustine:
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A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An alkylating agent of value against both hematologic malignancies and solid tumors.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An anticancer drug that belongs to the family of drugs called alkylating agents.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Cytotoxic alkylating agent of the nitrosourea group used as an antineoplastic.CRISP ThesaurusNational Institutes of Health, 2006
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