Pharmacologic Substance
nimustine Audio
[ ny-mus-teen ]
Subclass of:
Nitrosourea Compounds
Definitions related to nimustine:
  • A nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. (NCI05)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A substance that is being studied in the treatment of brain cancer. It belongs to the family of drugs called nitrosoureas.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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