Pharmacologic Substance
carmustine Audio
[ kahr-muh-steen ]
Brand Names:
BiCNU; Gliadel
Effect:
Decreased DNA Integrity; Decreased DNA Replication
May Treat:
Brain Neoplasms; Carcinoma; Colonic Neoplasms; Ependymoma; Glioblastoma; Hodgkin Disease; Lung Neoplasms; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Multiple Myeloma
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to carmustine:
  • A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An anticancer drug that belongs to the family of drugs called alkylating agents.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Cell cycle phase nonspecific alkylating antineoplastic agent used in the treatment of brain tumors and various other cancers.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.