Pharmacologic Substance
meclizine
[ mek-luh-zeen ]
Brand Names:
Antivert; Bonine; Dramamine Less Drowsy; Dramamine Nausea Relief; Naus-ease; Travel-Ease; Verticalm; Wal-Dram 2; Zentrip
Effect:
Decreased Acetylcholine Activity; Decreased Histamine Activity
May Prevent:
Motion Sickness
May Treat:
Motion Sickness; Vertigo
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to meclizine:
  • A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic piperazine with anti-emetic, sedative and histamine H1antagonistic properties. Meclizine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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