Pharmacologic Substance
ketoconazole
[ kee-toh-koh-nuh-zohl, -zawl ]
Brand Names:
Extina; Keto-C; Ketochlor; Ketodan; Kuric; Mal-A-Ket; Mal-A-Ket Wipes; Nizoral; Pharmaseb; T8 Keto Flush; Vital-Ketodine; Xolegel
Effect:
Decreased Cell Membrane Integrity; Decreased Cell Wall Integrity
May Prevent:
AIDS-Related Opportunistic Infections
May Treat:
Acanthamoeba Keratitis;
Blastomycosis;
Candidiasis, Chronic Mucocutaneous;
Candidiasis, Cutaneous;
Candidiasis, Oral;
Candidiasis, Vulvovaginal;
Coccidioidomycosis;
Dermatitis, Seborrheic;
Histoplasmosis;
Leishmaniasis;
Paracoccidioidomycosis;
Tinea Pedis;
Tinea Versicolor
More Information:
Definitions related to ketoconazole:
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1-acetyl-4-(2,4-dichlorophenyl-2-imidazolylmethyl- 1,3- dioxolanylmethoxyphenyl) piperazine; broad spectrum, oral antifungal.CRISP ThesaurusNational Institutes of Health, 2006
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A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.