Pharmacologic Substance
mepivacaine
Brand Names:
Carbocaine; Carbocaine with NeoCobefrin; Polocaine; Scandonest; Scandonest L
Effect:
Decreased Organized Electrical Activity; Local Anesthesia
May Prevent:
Pain
May Treat:
Pain
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to mepivacaine:
  • A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An amide-type local anesthetic agent. At the injection site, mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
    NCI
    U.S. National Cancer Institute, 2021
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