Pharmacologic Substance
meprobamate
me·pro·ba·mate [ muh-proh-buh-meyt, mep-roh-bam-eyt ]
Brand Names:
Equagesic
Effect:
Decreased Spinal Cord Organized Electrical Activity
May Treat:
Anxiety Disorders;
Headache;
Muscle Rigidity;
Muscle Spasticity;
Spasm
More Information:
Definitions related to meprobamate:
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A carbamate derivate with hypnotic, anti-anxiety, sedative, anticonvulsant and some indirect muscle relaxant properties. Although the exact mechanism of meprobamate is largely unknown, it appears to act as a depressant at multiple sites in the central nervous system, mostly likely through the GABAergic neurotransmitter system, including the thalamus and limbic system.NCI ThesaurusU.S. National Cancer Institute, 2021
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A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Meprobamate, drug used in the treatment of anxiety. A central nervous system depressant, meprobamate acts selectively upon the spinal cord and the higher centres in the brain. Physical dependence may be produced after utilization of high doses for prolonged periods. Possible side effects include...Encyclopedia Britannica, Inc., 2020
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