Pharmacologic Substance
mesna Audio
[ mez-nuh ]
Brand Names:
Mesnex
Effect:
Increased Renal Organic Ion Excretion
May Prevent:
Cystitis; Drug-Related Side Effects and Adverse Reactions; Hemorrhage
May Treat:
Cystitis; Hemorrhage
More Information:
ChemID; DailyMed; PDR
Definitions related to mesna:
  • 2-mercaptoethanesulfonic acid sodium salt; scavenges glutathione; used as a detoxifying agent for uroprotection (especially in cancer combination chemotherapy), as a prophlylactic for hemorrhagic cystitis, and as an expectorant in treating chronic bronchitis.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.