Pharmacologic Substance
methimazole
[ me-thim-uh-zohl, -thahy-muh- ]
Brand Names:
Felimazole; Tapazole
Effect:
Decreased Iodine Organification; Decreased Protein Modification; Decreased Protein Synthesis; Decreased Thyroid Hormone Iodination
May Treat:
Goiter; Thyroid Crisis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to methimazole:
  • A thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).
    NCI
    U.S. National Cancer Institute, 2021
  • A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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