Pharmacologic Substance
midodrine
Effect:
Arteriolar Vasoconstriction; Increased Blood Pressure
May Treat:
Hypotension, Orthostatic; Urinary Incontinence
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to midodrine:
  • A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).
    NCI
    U.S. National Cancer Institute, 2021
  • An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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