Pharmacologic Substance
labetalol
[ luh-bet-uh-lawl, -lol ]
Brand Names:
Trandate
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Negative Chronotropy; Negative Inotropy
May Treat:
Angina Pectoris; Heart Failure; Hypertension, Malignant; Myocardial Infarction
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to labetalol:
  • A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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