Cell or Molecular Dysfunction
mitochondrial swelling
mi·to·chon·dr·ial swell·ing
Subclass of:
Cell physiology
Definitions related to mitochondrial swelling:
  • An increase in MITOCHONDRIAL VOLUME due to an influx of fluid; it occurs in hypotonic solutions due to osmotic pressure and in isotonic solutions as a result of altered permeability of the membranes of respiring mitochondria.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • The mitochondrial matrix refers to the substance occupying the space enclosed by the inner membrane of a mitochondrion, which contains enzymes, DNA, granules, and inclusions of protein crystals, glycogen, and lipid. Mitochondrial swelling refers to an increase in size of the mitochondrial matrix. This phenomenon is thought to be related to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix. Mitochondrial swelling may distend the outer membrane until it ruptures.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2025
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