Pharmacologic Substance
rivaroxaban
Brand Names:
Xarelto
Effect:
Decreased Coagulation Factor Activity
May Prevent:
Pulmonary Embolism; Stroke; Venous Thrombosis
May Treat:
Pulmonary Embolism; Venous Thrombosis
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to rivaroxaban:
  • A morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM. It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • An orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.