Biologically Active Substance
osteocalcin
Subclass of:
Calcium-Binding Proteins
Definitions related to osteocalcin:
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Osteocalcin (100 aa, ~11 kDa) is encoded by the human BGLAP gene. This protein is involved in bone development.NCI ThesaurusU.S. National Cancer Institute, 2021
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Small acidic protein found in bone, dentin, calcified ectopic tissue, and plasma; comprises 1-2% of total bone protein, and has high Gla content.CRISP ThesaurusNational Institutes of Health, 2006
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Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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