Biologically Active Substance
osteocalcin
Subclass of:
Calcium-Binding Proteins
Definitions related to osteocalcin:
  • Osteocalcin (100 aa, ~11 kDa) is encoded by the human BGLAP gene. This protein is involved in bone development.
    NCI
    U.S. National Cancer Institute, 2021
  • Small acidic protein found in bone, dentin, calcified ectopic tissue, and plasma; comprises 1-2% of total bone protein, and has high Gla content.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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