Pharmacologic Substance
perindopril
Brand Names:
Aceon; Prestalia
Effect:
Decreased Blood Pressure; Decreased Bradykinin Degradation; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Prevent:
Diabetic Nephropathies; Hypertrophy, Left Ventricular; Myocardial Infarction; Ventricular Dysfunction, Left
May Treat:
Diabetic Nephropathies;
Heart Failure;
Hypertension;
Ventricular Dysfunction, Left
More Information:
Definitions related to perindopril:
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A non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.NCI ThesaurusU.S. National Cancer Institute, 2021
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An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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