Infections with species in the genus PNEUMOCYSTIS, a fungus causing interstitial plasma cell pneumonia (PNEUMONIA, PNEUMOCYSTIS) and other infections in humans and other MAMMALS. Immunocompromised patients, especially those with AIDS, are particularly susceptible to these infections. Extrapulmonary sites are rare but seen occasionally.

Pneumocystis jirovecii is a fungus that is common throughout the world. Many people have been exposed to it as children. Some people have the fungus in their lungs. If you are healthy, it usually will not make you sick. But it can make you sick if you have a weakened immune system, for example if you: Have HIV; Have an autoimmune disease; Have cancer; Have a chronic (long-lasting) lung disease; Had an organ or bone marrow transplant; Take medicines which weaken your immune system, such as chemotherapy and steroids. Pneumocystis jirovecii can spread from person to person through the air. You can spread it to others even if it isn't making you sick. The most common type of infection that Pneumocystis jirovecii causes is pneumocystis pneumonia (PCP). Pneumonia is an infection in one or both of the lungs. It causes the air sacs of the lungs to fill up with fluid or pus. The symptoms of PCP can develop over several days or weeks. They may include: Fever; Cough; Trouble breathing; Chest pain; Chills; Fatigue. Contact your healthcare provider if you have symptoms that you think are related to PCP. Since PCP can be life-threatening, it's important to get early treatment. To find out if you have PCP, your provider will take a sample of fluid or tissue from your lungs. You may cough up the sample (called sputum), have fluid collected during a bronchoalveolar lavage, or have tissue taken with a biopsy. They will send the sample to the lab to check for Pneumocystis. The treatment for PCP is with antibiotics, either by mouth or intravenously (by IV). You need to take them for about 3 weeks. If you have a severe case of PCP, you might need treatment in the hospital. There is no vaccine to prevent PCP. Some people who are at high risk of getting PCP may need to take antibiotics to prevent it. Centers for Disease Control and Prevention