Antibiotic
porfiromycin
[ por-fih-roh-my-sin ]
Subclass of:
Mitomycins
Definitions related to porfiromycin:
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A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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