Antibiotic
mitomycin
Brand Names:
Jelmyto; Mitosol; Mutamycin
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Adenocarcinoma; Colorectal Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to mitomycin:
  • A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • (mitomycin c) Antineoplastic antibiotic produced by Streptomyces caespitosus that acts as an alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.