Antibiotic
mitomycin
Brand Names:
Jelmyto; Mitosol; Mutamycin
Effect:
Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Adenocarcinoma;
Colorectal Neoplasms;
Pancreatic Neoplasms;
Stomach Neoplasms;
Urinary Bladder Neoplasms
More Information:
Definitions related to mitomycin:
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A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(mitomycin c) Antineoplastic antibiotic produced by Streptomyces caespitosus that acts as an alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis.CRISP ThesaurusNational Institutes of Health, 2006
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