Pharmacologic Substance
procaine Audio
pro·caine [ proh-keyn, proh-keyn ]
Effect:
Conduction System Depolarization; Decreased Organized Electrical Activity
May Prevent:
Pain
May Treat:
Pain; Substance Withdrawal Syndrome
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to procaine:
  • A benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
    NCI
    U.S. National Cancer Institute, 2021
  • A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Local anesthetic of the ester type that has a slow onset and a short duration of action, mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.