Pharmacologic Substance
ryanodine
Subclass of:
Diterpenes; Alkaloids; Pyrroles
Definitions related to ryanodine:
  • A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Binds to and inhibits the calcium-sensitive calcium channel of muscle sarcoplasmic reticulum and homologous organelles in other cell types, blocking the fast calcium release step in intracellular signal transduction.
    CRISP Thesaurus
    National Institutes of Health, 2006
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