Antibiotic
sulbactam
Brand Names:
Unasyn
May Treat:
Acinetobacter Infections;
Escherichia coli Infections;
Intraabdominal Infections;
Klebsiella Infections;
Proteus Infections;
Skin Diseases, Bacterial;
Staphylococcal Infections
More Information:
Definitions related to sulbactam:
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A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A semi-synthetic beta-lactamase inhibitor. The beta-lactam ring of sulbactam irreversibly binds to beta-lactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other beta-lactam antibiotics by the enzyme. Combining this agent with a beta-lactamase susceptible antibiotic, such as penicillins or a cephalosporin, to treat infections caused by beta-lactamase producing organisms, results in a decreased turnover rate of the beta-lactamase sensitive antibiotic and enhances its antibacterial activity.NCI ThesaurusU.S. National Cancer Institute, 2021
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