Pharmacologic Substance
terfenadine
Effect:
Decreased Histamine Activity
May Treat:
Rhinitis, Allergic;
Rhinitis, Allergic, Seasonal;
Skin Diseases
Definitions related to terfenadine:
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A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways.NCI ThesaurusU.S. National Cancer Institute, 2021
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A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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