Pharmacologic Substance
thalidomide
tha·lid·o·mide [ thuh-lid-uh-mahyd ]
Brand Names:
Thalomid
Effect:
Decreased Endothelial Proliferation; Decreased Immunologically Active Molecule Activity
May Prevent:
Graft vs Host Disease
May Treat:
Arthritis, Rheumatoid;
Behcet Syndrome;
Carcinoma, Renal Cell;
Crohn Disease;
Erythema Multiforme;
Erythema Nodosum;
Graft vs Host Disease;
Histiocytosis, Langerhans-Cell;
Leprosy;
Lupus Erythematosus, Discoid;
Multiple Myeloma;
Stomatitis, Aphthous;
Waldenstrom Macroglobulinemia
More Information:
Definitions related to thalidomide:
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A drug that is used to treat multiple myeloma in patients who have just been diagnosed, and a painful skin disease related to leprosy. It is also being studied in the treatment of other types of cancer. Thalomid belongs to the family of drugs called angiogenesis inhibitors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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Piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn due to teratogenic effects; it has been reintroduced and used for a number of immunological and inflammatory disorders.CRISP ThesaurusNational Institutes of Health, 2006
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Thalidomide, compound in medicine initially used as a sedative and an antiemetic until the discovery that it caused severe fetal malformations. Thalidomide was developed in West Germany in the mid-1950s and was found to induce drowsiness and sleep. The drug appeared to be unusually safe, with few...Encyclopedia Britannica, Inc., 2020
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