Pharmacologic Substance
chlorthalidone
[ klawr-thal-i-dohn, klohr- ]
Brand Names:
Clorpres; Edarbyclor; Tenoretic; Thalitone
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Increased Distal Tubule Cl- Excretion; Increased Distal Tubule H+ Excretion; Increased Distal Tubule K+ Excretion; Increased Distal Tubule Na+ Excretion
May Treat:
Edema; Glomerulonephritis; Heart Failure; Hypertension; Liver Cirrhosis; Nephrotic Syndrome; Renal Insufficiency
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to chlorthalidone:
  • A benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A long acting thiazide-like diuretic of the sulfamoylbenzamide class that is devoid of the benzothiadiazine structure. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. This leads to an increase in sodium, chloride, bicarbonate, and potassium secretion resulting in the excretion of water. In addition, this agent, like other thiazide diuretics, decreases calcium and uric acid secretion. In addition, this agent inhibits many carbonic anhydrase (CA) isoenzymes. Chlorthalidone is used in the treatment of high blood pressure, edema and congestive heart failure. The elimination half-life is about 40 to 50 hours.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.