Pharmacologic Substance
thiouracil
[ thahy-oh-yoo r-uh-sil ]
Subclass of:
Uracil
Definitions related to thiouracil:
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A sulfur-containing uracil. An established antithyroid drug and highly selective inhibitor of nitric oxide synthase (NOS), thiouracil also covalently binds to dopaquinone, produced by tyrosinase catalyzed oxidation of tyrosine, thereby selectively accumulating in de novo-synthesized melanin in overactive melanin-producing cells and providing a means to localize melanoma cells. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Antimetabolite used to treat hyperthyroidism, angina pectoris, and congestive heart failure, and as an experimental metabolic probe.CRISP ThesaurusNational Institutes of Health, 2006
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Occurs in seeds of Brassica and Crucifera species. Thiouracil has been used as antithyroid, coronary vasodilator, and in congestive heart failure although its use has been largely supplanted by other drugs. It is known to cause blood dyscrasias and suspected of terato- and carcinogenesis.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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