Pharmacologic Substance
uracil mustard
u·ra·cil mus·tard
Effect:
Cellular Activity Alteration
May Treat:
Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mycosis Fungoides; Ovarian Neoplasms; Polycythemia Vera; Thrombocytosis
Definitions related to uracil mustard:
  • An alkylating derivative of the pyrimidine nucleobase uracil that is bound to nitrogen mustard, with antineoplastic activity. Uramustine alkylates and damages DNA by binding to the guanine and cytosine moieties of DNA. This leads to cross-linking of DNA, which inhibits DNA synthesis and promotes cell death in rapidly metabolizing cells, such as cancer cells.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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