Pharmacologic Substance
vidarabine
[ vahy-dar-uh-bahyn ]
Effect:
Decreased DNA Replication; Decreased Protein Synthesis
May Treat:
Chickenpox; Herpes Simplex; Herpes Zoster; Keratitis, Herpetic; Keratoconjunctivitis, Infectious
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to vidarabine:
  • A nucleoside analog with activity against herpes simplex virus and varicella zoster virus. Vidarabine is converted to a monophosphate by viral thymidine kinase and is further modified to a triphosphate form by host enzymes. Vidarabine triphosphate directly inhibits DNA polymerase and also acts as a chain terminator in DNA replication.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.