• A tumor that secretes VASOACTIVE INTESTINAL PEPTIDE, a neuropeptide that causes VASODILATION; relaxation of smooth muscles; watery DIARRHEA; HYPOKALEMIA; and HYPOCHLORHYDRIA. Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. In most cases, Vipomas are located in the PANCREAS but can be found in extrapancreatic sites.
  NLM Medical Subject Headings
  U.S. National Library of Medicine, 2025
• VIPoma is an extremely rare type of pancreatic neuroendocrine tumor that secretes vasoactive intestinal polypeptide (VIP) leading to the manifestations of watery diarrhea, hypokalemia and achlorhydia or hypochhlorhydia (known as WDHA syndrome).
  OrphaNet
  INSERM, 2021
• (vip-producing neuroendocrine tumor) An often clinically aggressive neuroendocrine tumor located in the pancreas or small intestine. It is composed of cells containing vasoactive intestinal peptide. It may cause intractable diarrhea and metabolic disturbances.
  NCI
  U.S. National Cancer Institute, 2021
• A vipoma is a non-beta pancreatic islet cell tumor secreting vasoactive intestinal peptide (VIP), resulting in a syndrome of watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). Diagnosis is by serum VIP levels. Tumor is localized with CT and endoscopic ultrasound. Treatment is surgical resection.
  Merck Manuals
  Merck & Co., Inc., 2025
• VIPomas are neuroendocrine tumors that secrete vasoactive intestinal peptide (VIP) autonomously. They originate in amine precursor uptake and decarboxylation (APUD) cells of the gastroenteropancreatic endocrine system and in adrenal or extra-adrenal neurogenic sites.
  Medscape
  WebMD, 2025
• A VIPoma is a rare cancer caused by a type of pancreatic neuroendocrine tumor, which is tumor that arises from cells that produce hormones - allowing the tumor itself to produce hormones. A VIPoma secretes vasoactive intestinal peptide (VIP), a hormone that stimulates the secretion (and inhibits the absorption) of sodium, chloride,...
  NIH Genetic and Rare Diseases
  National Center for Advancing Translational Sciences
• A rare neuroendocrine tumor that is highly malignant (usually with regional lymph node or liver involvement at diagnosis) and arises from within the pancreas over 90% of the time. The remaining 10% of cases arise in extrapancreatic locations, such as the retroperitoneum or thorax. It secretes an active hormone called vasoactive...
  Epocrates
  Athenahealth, Inc., 2019