Disease or Syndrome
wegener's granulomatosis
Subclass of:
Lung Diseases, Interstitial
Also called:
GPA; Wegener's Granulomatosis; Wegener Granulomatosis
Definitions related to granulomatosis with polyangiitis:
-
(wegener's granulomatosis) Multisystem disease chiefly affecting males, characterized by necrotizing granulomatous vasculitis involving the upper and lower respiratory tracts, glomerulonephritis, and variable degrees of systemic small vessel vasculitis; considered an aberrant hypersensitivity reaction to an unknown antigen.CRISP ThesaurusNational Institutes of Health, 2006
-
A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and KIDNEYS. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against MYELOBLASTIN.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
-
A rare, autoimmune, systemic medium and small size vasculitis. It is characterized by the formation of necrotizing granulomas in the respiratory tract, necrotizing angiitis, and glomerulonephritis.NCI ThesaurusU.S. National Cancer Institute, 2021
-
Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a rare disease. It is a type of vasculitis, or inflammation of the blood vessels. The inflammation limits the flow of blood to important organs, causing damage. It can affect any organ, but it mainly affects the sinuses, nose, trachea (windpipe), lungs, and kidneys. The cause of GPA is unknown. It can affect people at any age. Men and women are equally affected. It is more common in whites. Symptoms may include joint pain, weakness, tiredness, and cold symptoms such as a runny nose that doesn't get better. Doctors use blood tests, chest X-rays, and biopsies to diagnose GPA and rule out other causes of the symptoms. Early treatment is important. Most people improve with medicines to slow or stop the inflammation.MedlinePlusU.S. National Library of Medicine, 2021
-
Systemic vasculitis affecting small to medium-sized vessels, characterized by necrotizing granulomas in the respiratory tract, necrotizing angiitis, glomerulonephritis with little to no immune complex deposition, and typically positive for antineutrophil cytoplasmic antibody staining in a cytoplasmic pattern (C-ANCA; antiproteinase 3).NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
-
Granulomatosis with polyangiitis is characterized by necrotizing granulomatous inflammation, small- and medium-sized vessel vasculitis, and focal necrotizing glomerulonephritis, often with crescent formation. Typically, the upper and lower respiratory tract and the kidneys are affected, but any organ may be. Symptoms vary depending on...Merck & Co., Inc., 2020
-
Granulomatosis with polyangiitis is an uncommon disorder that causes inflammation of the blood vessels in your nose, sinuses, throat, lungs and kidneys.Mayo Foundation for Medical Education and Research
-
Granulomatosis with polyangiitis (GPA) is a type of vasculitis or swelling (inflammation) of the blood vessels. The disease can cause swelling of the blood vessels anywhere in the body but mainly impacts the sinuses, nose, trachea (windpipe), lungs, and kidneys. The swelling can limit the flow of blood to these body parts, causing...National Center for Advancing Translational Sciences
-
Granulomatosis with polyangiitis (GPA) (previously known as Wegener granulomatosis) is a systemic vasculitis that typically involves small and medium vessels. Although any organ may be targeted, the classic triad consists of upper and lower respiratory tract involvement and pauci-immune glomerulonephritis. Involvement of cutaneous,...Athenahealth, Inc., 2019
Return to OpenMD Medical Dictionary
> W
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.