• A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the SMALL INTESTINE but also the JOINTS; CARDIOVASCULAR SYSTEM; and the CENTRAL NERVOUS SYSTEM. The disease is characterized by fat deposits in the INTESTINAL MUCOSA and LYMPH NODES, malabsorption, DIARRHEA with fatty stools, MALNUTRITION, and ARTHRITIS.
  NLM Medical Subject Headings
  U.S. National Library of Medicine, 2021
• A systemic infection caused by the Gram-positive bacterium Tropheryma whipplei. It affects the small intestine resulting in malabsorption. Other sites or systems affected by the infection are the joints, central nervous system, and the cardiovascular system.
  NCI Thesaurus
  U.S. National Cancer Institute, 2021
• An infection that is caused by the Gram-positive bacterium Tropheryma whipplei, which primarily affects the small intestine resulting in malabsorption.
  NICHD Pediatric Terminology
  U.S. National Cancer Institute, 2021
• Whipple disease is a rare systemic illness caused by the bacterium Tropheryma whipplei. Main symptoms are arthritis, weight loss, abdominal pain, and diarrhea. Diagnosis is by small-bowel biopsy. Treatment is initially with ceftriaxone or penicillin followed by a minimum 1 year of trimethoprim/sulfamethoxazole.
  Merck Manuals
  Merck & Co., Inc., 2020
• Whipple disease is a systemic disease most likely caused by a gram-positive bacterium, Tropheryma whippelii. Although the first descriptions of the disorder described a malabsorption syndrome with small intestine involvement, the disease also affects the joints, central nervous system, and cardiovascular system.
  Medscape
  WebMD, 2019
• Whipple disease is a rare bacterial infection that most often affects your joints and digestive system. Whipple disease interferes with normal digestion by impairing the breakdown of foods, such as fats and carbohydrates, and hampering your body's ability to absorb nutrients.
  Mayo Clinic
  Mayo Foundation for Medical Education and Research
• Whipple disease is an infectious bacterial disease that affects many different organ systems and interferes with the body's ability to process (metabolize) fats. The disease usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. In the gastrointestinal...
  NIH Genetic and Rare Diseases
  National Center for Advancing Translational Sciences
• Whipple disease is a rare, multisystemic, chronic infectious disease first described by G.H. Whipple in 1907. Tropheryma whipplei is a gram-positive bacterium from the Actinomycetes clade with a genome rich in the nucleotides guanine and cytosine (G-C). T whipplei is found ubiquitously in the environment and in healthy carriers. A...
  Epocrates
  Athenahealth, Inc., 2019