Pharmacologic Substance
imipramine Audio
im·ip·ra·mine [ ih-mip-ruh-meen ]
Brand Names:
Tofranil
Effect:
Decreased Serotonin Degradation; Increased Central Nervous System Norepinephrine Activity
May Treat:
Attention Deficit Disorder with Hyperactivity; Depressive Disorder; Enuresis; Pain; Panic Disorder
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to imipramine:
  • A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
  • Dibenzazepine tricyclic antidepressant.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Imipramine, synthetic drug used in the treatment of depression and enuresis (bed-wetting). Introduced into medicine in the late 1950s, imipramine was the first tricyclic antidepressant, a class named for its three-ring molecular structure. Imipramine works by inhibiting the reuptake of certain...
    Encyclopedia Britannica
    Encyclopedia Britannica, Inc., 2025
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